Design of Polyoxyethylene-polyoxypropylene Block Co- Polymer Based in Situ Gelling System for Localized Ocular Drug Delivery

Ocular drug delivery is limited both by patient acceptability and by the limited time that the dosage form is retained within the precorneal region. The timely gelation and retention of in situ-gelling ophthalmic formulations would be fundamental to improve the efficacy of drugs. The aim of this investigation was to develop ocular drug delivery system with simplicity in installation for patient, prolonged contact time with corneal epithelium with appropriate rheological properties. Formulation was evaluated on different parameters like pH, Drug content uniformity, gelation capacity, Measurement of phase change temperature, Isotonicity, Rheology, in-vitro drug release and stability studies.